FACTS ABOUT ISORHAMNETIN-3-O-GLUCOSIDE REVEALED

TAK-243 preferentially certain to UBA1 in excess of the linked E1 enzymes UBA2, UBA3, and UBA6 in intact AML cells. Inhibition of UBA1 with TAK-243 decreased levels of ubiquitylated proteins, elevated markers of proteotoxic pressure and DNA hurt stress. In vivo, TAK-243 reduced leukemic burden and qualified leukemic stem cells without having eviden